Bedaquiline in the multidrug-resistant tuberculosis treatment: Belarus experience
نویسندگان
چکیده
منابع مشابه
Health outcomes of bedaquiline in the treatment of multidrug-resistant tuberculosis in selected high burden countries
BACKGROUND Less than one-third of patients who are estimated to be infected with multidrug-resistant tuberculosis (MDR-TB) receive MDR-TB treatment regimens, and only 48% of those who received treatment have successful outcomes. Despite current regimens, newer, more effective and cost-effective approaches to treatment are needed. The aim of the study was to project health outcomes and impact on...
متن کاملBedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis.
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (TMC207-C208; NCT00449644). The current phase 2, multicenter, open-label, single-arm trial (TMC207-C209; NCT00910871) reported here was conducted to confirm the safety and efficacy of bedaquiline.Newly diagnosed or previo...
متن کاملBedaquiline for the treatment of multidrug-resistant tuberculosis: another missed opportunity?
Affiliations: Médecins Sans Frontières, Paris, France. APHP, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Bactériologie-Hygiène, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France. Sorbonne Université, UPMC Université Paris 06, CR7, INSERM, U1135, Centre d’Immunologie et des Maladies Infectieuses, CIMI, Team E13 (Ba...
متن کاملPoor treatment outcomes among multidrug-resistant tuberculosis patients in Gomel Region, Republic of Belarus.
SETTINGS Tuberculosis (TB) health facilities in the Gomel Region, Republic of Belarus-settings with a high burden of multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection. OBJECTIVE To determine treatment outcomes among MDR-TB patients diagnosed in 2009-2010 and factors associated with unsuccessful outcomes (death, failure and loss to follow-up). DESIGN Retrospect...
متن کاملThe Incidence of Amikacin Ototoxicity in Multidrug-Resistant Tuberculosis Patients
Amikacin has been shown to irreversibly suppressCochlear activity.The aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.In this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (MDR-TB) were included.All patients received fixed dose of intravenous amikacin(500 mg...
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ژورنال
عنوان ژورنال: International Journal of Mycobacteriology
سال: 2016
ISSN: 2212-5531
DOI: 10.1016/j.ijmyco.2016.11.014